Exploring the influence of various factors on oocyte maturation rates and clinical outcomes in ART cycles

KADIN SAĞLIĞI DERNEKLERİ FEDERASYONU KONGRESİ, Antalya, Türkiye, 17 - 21 Nisan 2024, ss.60, (Özet Bildiri)

Exploring the influence of various factors on oocyte

maturation rates and clinical outcomes in ART cycles

Zehra Selen Mutlu, Cihan Çakır

Bursa Uludağ Üniversitesi Histoloji ve Embriyoloji AbD

AIM: The primary objective of our study is to identify factors that

have a detrimental effect on oocyte maturation rates in in vitro

fertilization cycles, while also evaluating the impact of oocyte

maturation rates on clinical outcomes.

MATERIAL AND METHOD: Within the scope of our study, we

conducted a retrospective analysis of fresh assisted reproductive

technology (ART) cycles performed at Bursa Uludağ University

ART Center between 2011 and 2024. Oocyte maturation rates of

all cycles were evaluated. Four separate groups were determined

according to oocyte maturation rates: Group 1 (n=1306) (oocyte

maturation rate >75%), Group 2 (n=1038) (oocyte maturation rate

50%-75%), Group 3 (n= 241) (oocyte maturation rate 25%-49%)

and Group 4 (n=96) (oocyte maturation rate <25%). We compared

patients’ baseline characteristics, baseline hormonal parameters,

and ovarian stimulation profiles between these groups to identify

potential factors affecting oocyte maturation. We also examined

embryological parameters and clinical outcomes in these groups

to determine the impact of oocyte maturation on overall ART

cycle performance.

RESULTS: A comparative analysis was performed to evaluate

baseline characteristics and ovarian stimulation profiles between

different groups. The analysis revealed that factors such as fe-

male age (p=0.021), infertility etiology (p=0.019), AMH level

(p=0.010) and trigger type (p<0.043) had a statistically significant

effect on oocyte maturation. In particular, Group 1 exhibited the

highest statistically significant fertilization (p=0.420), blastulation

(p<0.001) and implantation (p<0.001) rates per transfer. In con-

trast, comparable embryological parameters and clinical outcomes

were observed across Groups 2, 3, and 4.

CONCLUSION: In conclusion, our study identified several sig-

nificant factors that influence oocyte maturation rates in in vitro

fertilization cycles, encompassing patient characteristics, hormon-

al parameters, stimulation protocols, and trigger types. Moreover,

higher oocyte maturation rates, notably observed in Group 1, were

associated with enhanced fertilization, blastulation, and implan-

tation rates per transfer, underscoring the pivotal role of oocyte

maturation in optimizing clinical outcomes within ART cycles.

Keywords: ART, maturation, oocyte