The Influence of Polymorphisms of Interleukin-17A and-17F Genes on Susceptibility and Activity of Rheumatoid Arthritis

Inal E. E., Gorukmez O., DÜNDAR Ü., Gorukmez O., Yener M., ÖZEMRİ SAĞ Ş., ...More

GENETIC TESTING AND MOLECULAR BIOMARKERS, vol.19, no.8, pp.461-464, 2015 (SCI-Expanded) identifier identifier identifier


Background: The roles of interleukin (IL)-17A and IL-17F in the pathogenesis of rheumatoid arthritis (RA) have been previously studied. However, the relationships between polymorphisms (IL-17A G197A, the IL-17F 7488A/G, and the IL-17F 7383A/G) of these genes with RA have not been clarified yet. Aims: To investigate the impacts of these polymorphisms on the severity and susceptibility of RA in a Turkish population. Methods: One hundred sixty-one patients with RA and 88 healthy sex-, age-, and ethnicity-matched controls were enrolled in this study. The erythrocyte sedimentation rate, C-reactive protein (CRP), and disease activity scores 28 (DAS28) of all participants were recorded. The IL-17A G197A, the IL-17F 7488A/G, and 7383A/G polymorphisms were determined using the polymerase chain reaction-restriction fragment length polymorphism method. Results: We found no significant difference regarding genotypes or allelic frequency distributions of the IL-17A G197A, the IL-17F 7383A/G, and 7488A/G polymorphisms between patients and healthy controls (p>0.05). There were slight, but not significant, differences in terms of CRP levels associated with the distribution of the genotypes of the IL-17F 7488A/G, and regarding DAS28 levels according to the genotype distribution of the IL-17A G197A polymorphism (p=0.062, 0.087, 0.052, respectively). Conclusions: These findings suggest that future larger scale studies with increased power should be performed to determine if the IL-17F 7488A/G and the IL-17A G197A polymorphisms are associated with the disease activity in patients with RA.