Correlates of psychotic like experiences (ple) during pandemic: do sars-cov-2 infection increase the vulnerability for ple among adolescents?

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Yılmaz Kafalı H. Y. , Turan S. , Akkaya S., Mutlu M., Özkaya Parlakay A. N. , Çöp E., ...More

12. Uluslararası Psikofarmakoloji Kongresi & 8.Uluslararası Çocuk ve Ergen Psikofarmakolojisi Sempozyumu, Antalya, Turkey, 17 - 20 November 2021, pp.80

  • Publication Type: Conference Paper / Full Text
  • City: Antalya
  • Country: Turkey
  • Page Numbers: pp.80


ABSTRACT BACKGROUND AND AIM:To investigate whether the SARS-CoV-2 infection increased the risk of psychotic-like experiences (PLE) among adolescents. Secondly, we aimed to examine which variables (SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage) contribute to PLE during pandemic among adolescents. METHODS:Altogether, 684 adolescents aged 12-18 (SARS-CoV-2 group: n=361, mean age=15.41.9, 54.8% girls, control group (CG): n=323, mean age: 15.71.2, 47.4% girls) were recruited. The SARS-CoV-2 infection was confirmed by polymerase chain reaction test. The positive dimension of the Community Assessment of Psychic Experiences-42 (CAPE-42-Pos), Patient Health Questionnaire (PHQ), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) were completed by all volunteers using an online survey. For the SARS-CoV-2 group, C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were noted. RESULTS: CAPE-Pos-frequency and CAPE-Pos-Stress scores were significantly higher, whereas GAD-Total and PSQI-Total scores were significantly lower in the SARS-CoV-2 group than the CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-related symptoms were significantly positively correlated with CAPE-Pos-frequency and CAPE-Pos-Stress scores. Among whole participants, SARS-CoV-2 infection, cigarette usage, GAD-7, and PHQ-9 scores significantly contributed to PLE in often or nearly always frequency. CONCLUSIONS:This study is the first to show a relationship between SARS-CoV-2 infection and PLE among adolescents. Furthermore, monocyte count and the number of SARS-CoV-2 symptoms during acute infection period, which can show the severity of the illness, were associated with PLE frequency. Among the whole group, besides SARS-CoV-2 infection, depression, anxiety, and cigarette usage contributed to PLE during pandemic. Keywords: Covid19, Pandemic, Psychotic, PLE, Adolescents