12. Uluslararası Psikofarmakoloji Kongresi & 8.Uluslararası Çocuk ve Ergen Psikofarmakolojisi Sempozyumu, Antalya, Türkiye, 17 - 20 Kasım 2021, ss.80
ABSTRACT
BACKGROUND AND AIM:To investigate whether the SARS-CoV-2 infection increased the risk of psychotic-like experiences (PLE) among
adolescents. Secondly, we aimed to examine which variables (SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug
usage) contribute to PLE during pandemic among adolescents.
METHODS:Altogether, 684 adolescents aged 12-18 (SARS-CoV-2 group: n=361, mean age=15.41.9, 54.8% girls, control group (CG): n=323, mean
age: 15.71.2, 47.4% girls) were recruited. The SARS-CoV-2 infection was confirmed by polymerase chain reaction test. The positive dimension
of the Community Assessment of Psychic Experiences-42 (CAPE-42-Pos), Patient Health Questionnaire (PHQ), Generalized Anxiety Disorder-7
(GAD-7), and Pittsburg Sleep Quality Index (PSQI) were completed by all volunteers using an online survey. For the SARS-CoV-2 group, C-reactive
Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were noted.
RESULTS: CAPE-Pos-frequency and CAPE-Pos-Stress scores were significantly higher, whereas GAD-Total and PSQI-Total scores were significantly
lower in the SARS-CoV-2 group than the CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-related symptoms
were significantly positively correlated with CAPE-Pos-frequency and CAPE-Pos-Stress scores. Among whole participants, SARS-CoV-2 infection,
cigarette usage, GAD-7, and PHQ-9 scores significantly contributed to PLE in often or nearly always frequency.
CONCLUSIONS:This study is the first to show a relationship between SARS-CoV-2 infection and PLE among adolescents. Furthermore, monocyte
count and the number of SARS-CoV-2 symptoms during acute infection period, which can show the severity of the illness, were associated with
PLE frequency. Among the whole group, besides SARS-CoV-2 infection, depression, anxiety, and cigarette usage contributed to PLE during
pandemic.
Keywords: Covid19, Pandemic, Psychotic, PLE, Adolescents