Rituximab as a new therapeutic option in granulomatosis with polyangiitis: a report of two cases.

Dalkilic E., Alkis N., Kamali S.

Modern rheumatology, cilt.22, sa.3, ss.463-6, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10165-011-0507-7
  • Dergi Adı: Modern rheumatology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.463-6
  • Anahtar Kelimeler: Rituximab, Granulomatosis with polyangiitis, Ocular involvement, WEGENERS-GRANULOMATOSIS, VASCULITIS, CYCLOPHOSPHAMIDE, METHOTREXATE, EFFICACY, TRIAL
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Findings of several reports suggest that rituximab, a chimeric monoclonal anti-CD20 antibody causing B-lymphocyte depletion, might represent a treatment option for people with granulomatosis with polyangiitis (GPA) (former Wegener's granulomatosis). This study presents the results of rituximab treatment in two patients with treatment-refractory GPA. First patient received rituximab for a granulomatous posterior orbital mass lesion, and eye symptoms were resolved after three courses of treatment. The second patient had eye and paranasal sinus involvement and benefited from two courses of rituximab treatment, with significant clinical improvement. Rituximab may represent an effective novel treatment for remission induction in GPA.