Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury
NEUROLOGICAL RESEARCH, cilt.34, sa.3, ss.238-245, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 3
- Basım Tarihi: 2012
- Doi Numarası: 10.1179/1743132812y.0000000003
- Dergi Adı: NEUROLOGICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.238-245
- Anahtar Kelimeler: Citicoline, Choline, Cytidine, Sciatic nerve, Nerve regeneration, EXPERIMENTAL FOCAL ISCHEMIA, TRANSIENT CEREBRAL-ISCHEMIA, PHOSPHOLIPASE A(2), EMBOLIC STROKE, CITICOLINE, URIDINE, BRAIN, METABOLITES, PHOSPHOCHOLINE, STIMULATION
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Objective: Topical cytidine-5'-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its beneficial actions.