Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury

Caner B., Kafa M. I., BEKAR A., Kurt M. A., Karli N., CANSEV M., ...More

NEUROLOGICAL RESEARCH, vol.34, no.3, pp.238-245, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.1179/1743132812y.0000000003
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.238-245
  • Keywords: Citicoline, Choline, Cytidine, Sciatic nerve, Nerve regeneration, EXPERIMENTAL FOCAL ISCHEMIA, TRANSIENT CEREBRAL-ISCHEMIA, PHOSPHOLIPASE A(2), EMBOLIC STROKE, CITICOLINE, URIDINE, BRAIN, METABOLITES, PHOSPHOCHOLINE, STIMULATION
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: Topical cytidine-5'-diphosphocholine (CDP-choline) improves functional recovery and promotes nerve regeneration in sciatic nerve injury in rats. The aims of this study were to test whether systemic treatment with CDP-choline was effective in improving the recovery of injured sciatic nerve, and to determine whether the cytidine and/or choline moieties of CDP-choline contribute to its beneficial actions.