Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response.

Atasayar G., Eryılmaz I. E., Karli N., Egeli Ü., Zarifoğlu M., Çeçener G., ...Daha Fazla

Journal of the neurological sciences, cilt.366, ss.149-154, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 366
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jns.2016.05.019
  • Dergi Adı: Journal of the neurological sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.149-154
  • Anahtar Kelimeler: Migraine, Prophylactic therapy response, MDR1, Polymorphism, MULTIDRUG-RESISTANCE, C3435T POLYMORPHISM, CYTOCHROME-P450, FREQUENCY, ALLELES, PHARMACOGENETICS, PHENOTYPE, GENOTYPE, 2C19, 2D6
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Prophylactic therapy response varies in migraine patients. The present study investigated the relationship between the resistance to the drugs commonly used in prophylactic therapy and the possible polymorphic variants of proteins involved in the metabolism of these drugs. Migraine patients with the MDR1 3435TT genotype exhibited a better treatment response to topiramate than migraine patients with the CC and CT genotypes (p = 0.020). The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (beta(2) = 1.152, p = 0.015). However, there was no significant relationship between the treatment response to topiramate and either the CYP2D6 or CYP2C19 polymorphism, and there were no significant correlations between the treatment responses to amitriptyline, propranolol, and valproic acid and the MDR1, CYP2D6 and CYP2C19 gene polymorphisms. This is the first study to investigate the effect of the polymorphic variants on prophylactic therapy response in migraine patients. (C) 2016 Published by Elsevier B.V.