Association of urokinase gene 3 '-UTR T/C polymorphism with calcium oxalate urolithiasis in children


Ozturk M., Kordan Y., Cangul H., Dogan H. S. , KILIÇARSLAN H. , VURUŞKAN H. , ...More

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.40, no.3, pp.563-568, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1007/s11255-008-9335-x
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.563-568

Abstract

Introduction and objectives Urokinase is synthesized by various cells such as kidney, pneumocytes, and phagocytes. It cleaves plasminogen to plasmin and hence stimulates fibrinolysis. Urokinase breaks down the matrix protein within the stone and thus prevents stone formation and growth. Urokinase concentrations are lower and urokinase gene 3'-UTR T/C polymorphism is higher in patients with recurrent stones. Our aim was to investigate the role of urokinase gene 3'-UTR T/C polymorphism in childhood recurrent stone disease.