Association of urokinase gene 3 '-UTR T/C polymorphism with calcium oxalate urolithiasis in children

Ozturk M., Kordan Y., Cangul H., Dogan H. S., KILIÇARSLAN H., VURUŞKAN H., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.40, sa.3, ss.563-568, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s11255-008-9335-x
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.563-568
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Introduction and objectives Urokinase is synthesized by various cells such as kidney, pneumocytes, and phagocytes. It cleaves plasminogen to plasmin and hence stimulates fibrinolysis. Urokinase breaks down the matrix protein within the stone and thus prevents stone formation and growth. Urokinase concentrations are lower and urokinase gene 3'-UTR T/C polymorphism is higher in patients with recurrent stones. Our aim was to investigate the role of urokinase gene 3'-UTR T/C polymorphism in childhood recurrent stone disease.