Effects of thiamine treatment on oxidative stress in experimental diabetes


Sarandol E. , Tas S. , Serdar Z., Dirican M.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, no.3, pp.235-241, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_036
  • Title of Journal : BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Page Numbers: pp.235-241
  • Keywords: streptozotocin, diabetes mellitus, thiamine, oxidative stress, paraoxonase, HUMAN-SERUM PARAOXONASE, PHOSPHATE-ESTERS, VANADYL SULFATE, PLASMA, ARYLESTERASE, METABOLISM, COMPLICATIONS, DYSLIPIDEMIA, GLYCATION, TRANSPORT

Abstract

AIM: Hyperglycemia, oxidative stress and hyperlipidemia are features of diabetes mellitus. Thiamine has beneficial effects on carbohydrate metabolism and it was proposed that this vitamin has antihyperlipidemic and antioxidant effects. Our aim was to investigate the effects of thiamine on oxidative stress and metabolic changes in streptozotocin (STZ) induced diabetic rats.