Immunohistochemical Determination of HIF, TSP-1, ADAMTS1, and ADAMTS8 Expressions in the Brains of Alzheimer's Disease Patients: A Preliminary Autopsy Study

TÜRKMEN İNANIR N. , Eren F., FEDAKAR R. , Eren B., Demircan K., Gurses M. S. , ...More

ERCIYES MEDICAL JOURNAL, vol.38, no.1, pp.1-5, 2016 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5152/etd.2016.0061
  • Title of Journal : ERCIYES MEDICAL JOURNAL
  • Page Numbers: pp.1-5


Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease that mostly affects the elderly population. Recent studies performed in AD highlight the pathophysiological relevance of disintegrin and metalloproteinase with thrombospondin type 1-like motifs (ADAMTS) genes and their products, namely hypoxia inducible factor-1 (HIF-1) and thrombospondin-1 (TSP-1). Thus, the aim of this study was to describe and identify the distribution, characteristics, and any changes in the expression and immunoreactivity for HIF-1, TSP-1, and ADAMTS1 and 8 in AD brains.