Enantioselective synthesis of 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles from 2-iminochromenes


Koz G., KOZ Ö., Coskun N.

SYNTHETIC COMMUNICATIONS, vol.46, no.10, pp.909-915, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.1080/00397911.2016.1177728
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.909-915

Abstract

A series of medicinally important 2-amino-4-(nitromethyl)-4H-chromene-3-carbonitriles were synthesized using enantioselective conjugate addition of nitromethane to 2-iminochromenes. The reactions were performed using L8-Cu (II) catalytic system and moderate to good enantioselectivities (62-88%) and yields (66-96%) were obtained.