IN VIVO EVALUATION OF ELECTROSPUN POLY (VINYL ALCOHOL)/SODIUM ALGINATE NANOFIBROUS MAT AS WOUND DRESSING


Ustundag G. C., Karaca E., Özbek S., Cavusoglu I.

TEKSTIL VE KONFEKSIYON, vol.20, pp.290-298, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2010
  • Journal Name: TEKSTIL VE KONFEKSIYON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.290-298
  • Keywords: Electrospinning, Nanofiber, Alginate, Wound dressing, In vivo, SODIUM ALGINATE, POLY(ETHYLENE OXIDE), MEMBRANE, FIBERS, FABRICS
  • Bursa Uludag University Affiliated: Yes

Abstract

In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 PVA / %1 NaAlg nanofibrous mats were produced by electrospinning method. In order to improve water resistance of the electrospun mats, the cross-linking was performed. SEM analyses, thickness and air permeability tests were applied for the nanofibrous mats produced as wound dressing and Suprasorb-A commercial alginate wound dressing. In vivo experiments, the healing performances of the wounds dressed by using cotton gauze, Bactigras, Suprasorb-A and the electrospun PVA/NaAlg nanofibrous mat were macroscopically evaluated and compared. The wound healing potential of the electrospun mat was better than that of cotton gauze including a drug and looked like antibacterial Bactigras. The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing.