Investigation of the Defective Growth Pattern and Multidrug Resistance in a Clinical Isolate of Candida glabrata Using Whole-Genome Sequencing and Computational Biology Applications
MICROBIOLOGY SPECTRUM, cilt.10, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10
- Basım Tarihi: 2022
- Doi Numarası: 10.1128/spectrum.00776-22
- Dergi Adı: MICROBIOLOGY SPECTRUM
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: amphotericin resistance, azole resistance, Candida glabrata, cholesterol dependent, ERG1, whole-genome sequencing, AMPHOTERICIN-B, ECHINOCANDIN RESISTANCE, REDUCED SUSCEPTIBILITY, MISSENSE MUTATION, BLOOD CULTURES, FKS MUTATIONS, STEROL UPTAKE, ERG6 GENE, AZOLES, SENSITIVITY
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
In this study, a cholesterol-dependent C. glabrata clinical isolate that confers azole and AmB resistance was investigated using artificial intelligence (AI) technologies and cloud computing applications. This is the first of the known cholesterol-dependent C. glabrata isolate to be found in Turkey.