Investigation of the Defective Growth Pattern and Multidrug Resistance in a Clinical Isolate of Candida glabrata Using Whole-Genome Sequencing and Computational Biology Applications

MERDAN O., Sisma A. S., AKSOY S., Kizil S., TÜZEMEN N. Ü., YILMAZ E., ...More

MICROBIOLOGY SPECTRUM, vol.10, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2022
  • Doi Number: 10.1128/spectrum.00776-22
  • Journal Name: MICROBIOLOGY SPECTRUM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: amphotericin resistance, azole resistance, Candida glabrata, cholesterol dependent, ERG1, whole-genome sequencing, AMPHOTERICIN-B, ECHINOCANDIN RESISTANCE, REDUCED SUSCEPTIBILITY, MISSENSE MUTATION, BLOOD CULTURES, FKS MUTATIONS, STEROL UPTAKE, ERG6 GENE, AZOLES, SENSITIVITY
  • Bursa Uludag University Affiliated: Yes

Abstract

In this study, a cholesterol-dependent C. glabrata clinical isolate that confers azole and AmB resistance was investigated using artificial intelligence (AI) technologies and cloud computing applications. This is the first of the known cholesterol-dependent C. glabrata isolate to be found in Turkey.