In this study, the mechanical behavior of titanium (ASTM Grade 2) alloy sheet, resistance spot welded with 5754 aluminum alloy, was investigated with respect to nugget formation and mechanical properties. The welding operations were performed using resistance spot welding at various welding currents (10, 12.5 and 15 kA), welding times (10, 15 and 20 cycles) and electrode forces (5, 10 and 15 kN). The weld nugget diameter and nugget center height, hardness, and tensile-shear test results of the welded samples were examined, and the mechanical properties were compared. As a result of the tests, it was seen that the welding parameters have a significant effect on the mechanical properties of the titanium-aluminum alloy welding joints. The tensile-shear load of the resistance spot welded joints increased as the welding current increased, and welding time increased for 15 cycles. On the other hand, when the electrode force increased, the tensile-shear load decreased markedly.