A Rare Case of Lymphoma with Invasive Pulmonary Aspergillosis Developing Azole Resistance Azol Direnci Gelişen İnvaziv Pulmoner Aspergilloz’lu Nadir Bir Lenfoma Olgusu
Journal of Uludag University Medical Faculty, cilt.52, 2026 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52
- Basım Tarihi: 2026
- Doi Numarası: 10.32708/uutfd.1960572
- Dergi Adı: Journal of Uludag University Medical Faculty
- Derginin Tarandığı İndeksler: Scopus
- Anahtar Kelimeler: Aspergillosis, Azole Resistance, Hematologic Malignancy, Invasive Pulmonary Aspergillosis, Voriconazole
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
This study reports a rare case of azole-resistant invasive pulmonary aspergillosis (IPA) in a patient with diffuse large B-cell lymphoma and to underscore the clinical relevance of emerging azole resistance in hematologic malignancies. Clinical, microbiological, and radiological findings were reviewed in a patient who developed IPA. Antifungal susceptibility testing was performed, and the clinical response was evaluated after modification of antifungal therapy. Despite antifungal treatment with voriconazole, azole resistance was detected. Switching back to amphotericin B resulted in marked clinical and radiological improvement, supporting the diagnosis of azole-resistant IPA. Azole resistance, though uncommon, is an increasingly important therapeutic concern in immunocompromised hosts. Early recognition and timely initiation of alternative agents such as amphotericin B may improve outcomes.