Protective Effects of Melatonin Therapy in Model for Neonatal Hyperoxic Lung Injury


Suleymanoglu S., Cekmez F., Cetinkaya M., Tayman C., Canpolat F. E., Kafa İ. M., ...More

ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE, vol.20, no.5, pp.24-29, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 5
  • Publication Date: 2014
  • Journal Name: ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.24-29
  • Bursa Uludag University Affiliated: Yes

Abstract

Context Bronchopulmonary dysplasia (BPD) is a common outcome of premature birth. Currently, no effective preventive therapy is available for BPD, but the major role of O-2 toxicity in the development of BPD has gained attention, particularly for developing new antioxidants for prevention. The major protective mechanism of melatonin (MT) includes free-radical scavenging activity and activation of the cyclooxygenase-prostoglandin enzyme system.