Is there any prognostic significance in pleural involvement and/or effusion in patients with ALK-positive NSCLC?

Güner G., Aktaş B. Y., Başal F. B., DEMİRKAZIK A., Gürsoy P., Demirci U., ...Daha Fazla

Journal of Cancer Research and Clinical Oncology, cilt.149, sa.14, ss.13271-13277, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149 Sayı: 14
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00432-023-05190-3
  • Dergi Adı: Journal of Cancer Research and Clinical Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.13271-13277
  • Anahtar Kelimeler: NSCLC, ALK-positive, Pleural involvement, Pleural effusion, Prognosis, CELL LUNG-CANCER, BRAIN METASTASES, SURVIVAL, CHEMOTHERAPY, CRIZOTINIB, IDENTIFICATION, GENE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Purpose: Anaplastic lymphoma kinase (ALK) mutations occurs in approximately 3–5% of patients with non-small cell lung cancer (NSCLC). Pleural involvement/effusion is common in ALK-positive patients with NSCLC at baseline. The aim of the study was to evaluate the characteristics of ALK-positive patients who have Ple-I/E. Methods: In this multicenter study, patients with ALK-positive NSCLC who have Ple-I/E were retrospectively analyzed. Clinical and demographic characteristics of the disease, response rates, median progression-free survival (PFS), and overall survival (OS) were evaluated in 362 ALK-positive patients with NSCLC. Results: Of the patients, 198 (54.7%) were male. The median age at the time of diagnosis was 54 (range 21–85) years. All patients’ histology was adenocarcinoma (100%). At baseline, 57 (15.7%) patients had Ple-I/E. There was no association between Ple-I/E and gender, lung metastasis, or distant lymphadenopathy (LAP) metastasis. The frequencies of liver, brain, and bone metastases were significantly higher in ALK-positive patients without Ple-I/E compared to those with Ple-I/E (respectively 18.2% vs 4.8%, p = 0.008; 19.1% vs 4.8%, p = 0.001; 20.6% vs 8.9%, p = 0.002). The median PFS was longer in ALK-positive patients who had Ple-I/E (18.7 vs 10.6 months, p = 0.017). Similarly, the median OS was longer in ALK-positive patients who had Ple-I/E (44.6 vs 22.6 months, p = 0.051). Conclusion: Brain, liver, and bone metastases were lower in ALK-positive patients with Ple-I/E. Patients presented with Ple-I/E were prone to have better PFS and OS.