Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain

Wilkerson, J.; Ghosh, S.; Bagdas, D.; Mason, B.; Crowe, M.; Hsu, K.; Wise, L.; Kinsey, S.; Damaj, M.; Cravatt, B.; Lichtman, A.

doi:10.1111/bph.13469

Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain

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Wilkerson J. L., Ghosh S., Bagdas D., Mason B. L., Crowe M. S., Hsu K. L., ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.173, no.10, pp.1678-1692, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 173 Issue: 10
Publication Date: 2016
Doi Number: 10.1111/bph.13469
Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1678-1692
Bursa Uludag University Affiliated: No

Abstract

Background and PurposeInhibition of diacylglycerol lipase (DGL) prevents LPS-induced pro-inflammatory responses in mouse peritoneal macrophages. Thus, the present study tested whether DGL inhibition reverses allodynic responses of mice in the LPS model of inflammatory pain, as well as in neuropathic pain models.