Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain


Wilkerson J. L. , Ghosh S., Bagdas D., Mason B. L. , Crowe M. S. , Hsu K. L. , ...More

BRITISH JOURNAL OF PHARMACOLOGY, vol.173, no.10, pp.1678-1692, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 173 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.1111/bph.13469
  • Journal Name: BRITISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1678-1692
  • Bursa Uludag University Affiliated: No

Abstract

Background and PurposeInhibition of diacylglycerol lipase (DGL) prevents LPS-induced pro-inflammatory responses in mouse peritoneal macrophages. Thus, the present study tested whether DGL inhibition reverses allodynic responses of mice in the LPS model of inflammatory pain, as well as in neuropathic pain models.