Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain

Wilkerson, J.; Ghosh, S.; Bagdas, D.; Mason, B.; Crowe, M.; Hsu, K.; Wise, L.; Kinsey, S.; Damaj, M.; Cravatt, B.; Lichtman, A.

doi:10.1111/bph.13469

Diacylglycerol lipase beta inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain

Atıf İçin Kopyala

Wilkerson J. L., Ghosh S., Bagdas D., Mason B. L., Crowe M. S., Hsu K. L., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.173, sa.10, ss.1678-1692, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 173 Sayı: 10
Basım Tarihi: 2016
Doi Numarası: 10.1111/bph.13469
Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1678-1692
Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Background and PurposeInhibition of diacylglycerol lipase (DGL) prevents LPS-induced pro-inflammatory responses in mouse peritoneal macrophages. Thus, the present study tested whether DGL inhibition reverses allodynic responses of mice in the LPS model of inflammatory pain, as well as in neuropathic pain models.