The ATP Assay, but not the MTT assay, Detects Further Cytotoxicity of the Combination of Anthracycline-based Therapy with Histone Deacetylase Inhibitor (Valproic Acid) in Breast Cancer Cells


ARI F. , Ikitimur E. I. , Ulukaya E.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.35, no.4, pp.293-299, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2010
  • Title of Journal : TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Page Numbers: pp.293-299

Abstract

Purpose: It has been investigated that whether or not the combination of valproic acid (a histone deacetylase inhibitor) with anthracycline-based chemotherapy (FEC: 5-fluorouracil+epirubicine+ cyclophosphamide) would change the cytotoxic effects of FEC in breast cancer cells.