Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome

Ursavas A., Karadag M., Ilcol Y. O., Ercan İ., Burgazlioglu B., Coskun F., ...More

LUNG, vol.185, no.5, pp.309-314, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 185 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1007/s00408-007-9026-x
  • Journal Name: LUNG
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.309-314
  • Keywords: insulin-like growth factor, obesity, sleep apnea, GROWTH-FACTOR-I, CORONARY-ARTERY DISEASE, HORMONE SECRETION, SOMATOMEDIN-C, HEART-DISEASE, SERUM-LEVELS, BODY-MASS, INSULIN, ASSOCIATION, GENDER
  • Bursa Uludag University Affiliated: Yes

Abstract

The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.