Effect of the P2Y(12) antagonist ticagrelor on neointimal hyperplasia in a rabbit carotid anastomosis model

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Surer S., Toktas F., Ay D., Eris C., Yavuz S., Turk T., ...More

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol.19, no.2, pp.198-204, 2014 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 19 Issue: 2
• Publication Date: 2014
• Doi Number: 10.1093/icvts/ivu087
• Journal Name: INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.198-204
• Keywords: Intimal hyperplasia, Ticagrelor, Carotid artery, Rabbit model, INTIMAL HYPERPLASIA, CLOPIDOGREL, THROMBOSIS, INJURY
• Bursa Uludag University Affiliated: Yes

Abstract

OBJECTIVES: In the present study, we aimed to deterimine the dose-related effects of ticagrelor, the first reversible inhibitor of the P2Y(12) receptor, found in smooth muscle cells as well as platelets, during neointimal hyperplasia in a rabbit carotid anastomosis model.