Effect of the P2Y(12) antagonist ticagrelor on neointimal hyperplasia in a rabbit carotid anastomosis model


Surer S., Toktas F., Ay D., Eris C., Yavuz S., Turk T., ...More

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol.19, no.2, pp.198-204, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 2
  • Publication Date: 2014
  • Doi Number: 10.1093/icvts/ivu087
  • Title of Journal : INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
  • Page Numbers: pp.198-204
  • Keywords: Intimal hyperplasia, Ticagrelor, Carotid artery, Rabbit model, INTIMAL HYPERPLASIA, CLOPIDOGREL, THROMBOSIS, INJURY

Abstract

OBJECTIVES: In the present study, we aimed to deterimine the dose-related effects of ticagrelor, the first reversible inhibitor of the P2Y(12) receptor, found in smooth muscle cells as well as platelets, during neointimal hyperplasia in a rabbit carotid anastomosis model.