Orf Infection in a Patient with Stat1 Gain-of-Function
JOURNAL OF CLINICAL IMMUNOLOGY, cilt.35, sa.1, ss.80-83, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.1007/s10875-014-0111-7
- Dergi Adı: JOURNAL OF CLINICAL IMMUNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.80-83
- Anahtar Kelimeler: Chronic mucocutaneous candidiasis, orf infection, STAT1 gain-of-function, primary immunodeficiency, CHRONIC MUCOCUTANEOUS CANDIDIASIS, VIRUS-INFECTION, GIANT ORF, IMMUNITY, AUTOANTIBODIES, DEFICIENCY, MUTATIONS, LYMPHOMA, HUMANS, IL-17A
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Chronic Mucocutaneous Candidiasis (CMC) refers to a group of immunodeficiencies, characterized by persistent or recurrent infections of the skin, nails, and mucosae caused by Candida. It is typically caused by inborn errors of IL-17 immunity. Orf, also known as contagious ecthyma, is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep and goats; it is transmitted to humans through contact with an infected animal or fomites. While orf is usually a benign self-limiting illness, it can be progressive and even life-threatening in immune-compromised hosts.