Orf Infection in a Patient with Stat1 Gain-of-Function

Kilic S. Ş., Puel A., Casanova J.

JOURNAL OF CLINICAL IMMUNOLOGY, cilt.35, sa.1, ss.80-83, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s10875-014-0111-7
  • Dergi Adı: JOURNAL OF CLINICAL IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.80-83
  • Anahtar Kelimeler: Chronic mucocutaneous candidiasis, orf infection, STAT1 gain-of-function, primary immunodeficiency, CHRONIC MUCOCUTANEOUS CANDIDIASIS, VIRUS-INFECTION, GIANT ORF, IMMUNITY, AUTOANTIBODIES, DEFICIENCY, MUTATIONS, LYMPHOMA, HUMANS, IL-17A
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Chronic Mucocutaneous Candidiasis (CMC) refers to a group of immunodeficiencies, characterized by persistent or recurrent infections of the skin, nails, and mucosae caused by Candida. It is typically caused by inborn errors of IL-17 immunity. Orf, also known as contagious ecthyma, is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep and goats; it is transmitted to humans through contact with an infected animal or fomites. While orf is usually a benign self-limiting illness, it can be progressive and even life-threatening in immune-compromised hosts.