Orf Infection in a Patient with Stat1 Gain-of-Function


Kilic S. Ş. , Puel A., Casanova J.

JOURNAL OF CLINICAL IMMUNOLOGY, vol.35, no.1, pp.80-83, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1007/s10875-014-0111-7
  • Title of Journal : JOURNAL OF CLINICAL IMMUNOLOGY
  • Page Numbers: pp.80-83
  • Keywords: Chronic mucocutaneous candidiasis, orf infection, STAT1 gain-of-function, primary immunodeficiency, CHRONIC MUCOCUTANEOUS CANDIDIASIS, VIRUS-INFECTION, GIANT ORF, IMMUNITY, AUTOANTIBODIES, DEFICIENCY, MUTATIONS, LYMPHOMA, HUMANS, IL-17A

Abstract

Chronic Mucocutaneous Candidiasis (CMC) refers to a group of immunodeficiencies, characterized by persistent or recurrent infections of the skin, nails, and mucosae caused by Candida. It is typically caused by inborn errors of IL-17 immunity. Orf, also known as contagious ecthyma, is a zoonotic infection caused by a dermatotropic parapoxvirus that commonly infects sheep and goats; it is transmitted to humans through contact with an infected animal or fomites. While orf is usually a benign self-limiting illness, it can be progressive and even life-threatening in immune-compromised hosts.