The aim of this study is to investigate the effect of building-based assessment on flood hazards. Degirmendere, which is one of the most important basins of the Eastern Black Sea Region of Turkey, was selected as the study area. Flood hazards for discharge values with different return periods of this region were found using; the damage percentages table recommended by the Huntington Civil Engineers Association (HCEA), the Van Eck and Kok depth-loss curves, and the equation obtained by Pistrika and Jonkman. The calculations were performed both for building-based and for the region-based and compared. Furthermore, the damage rates obtained for each building on a building-based were graded and shown on the map. It was determined that the damage on individual building-based estimation for Q1,000 calculated more than to the one on region-based 154% and 17% for the damage percentages table recommended by the HCEA, Van Eck and Kok depth-loss curves, respectively. Otherwise, it gave 11% less damage estimation for the equation obtained by Pistrika and Jonkman. Furthermore, it was concluded that the increase in damage from Q(50) to Q(100), from Q(100) to Q(500) , and from Q(500) to Q(1.000) was between 16%-30% according to building-based damage estimation.