Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.

Kahveci F., Kahveci N. , Alkan T. , Goren B., Korfali E., Ozluk K.

Surgical neurology, vol.56, no.3, pp.206-14, 2001 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1016/s0090-3019(01)00555-9
  • Title of Journal : Surgical neurology
  • Page Numbers: pp.206-14


BACKGROUND The aim of this study was to compare the cerebral protective effects of two known protective anesthetics, isoflurane and propofol, when these were used in combination with moderate hypothermia (33-34 degreesC) after diffuse traumatic brain injury (TBI) in the rat. We assessed cerebral protection by measuring local cerebral blood flow (LCBF), mean arterial blood pressure (MABP), cerebral perfusion pressure (CPP) and intracranial pressure (ICP).