Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.

Kahveci F., Kahveci N., Alkan T., Goren B., Korfali E., Ozluk K.

Surgical neurology, cilt.56, sa.3, ss.206-14, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0090-3019(01)00555-9
  • Dergi Adı: Surgical neurology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.206-14
  • Anahtar Kelimeler: propofol, isoflurane, hypothermia, head injury, rat, LCBF, GLUCOSE-UTILIZATION, MILD HYPOTHERMIA, HEAD-INJURY, HIPPOCAMPAL GLUTAMATE, MODERATE HYPOTHERMIA, ELECTRICAL-ACTIVITY, ISCHEMIA, METABOLISM, HALOTHANE, ANTIOXIDANT
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

BACKGROUND The aim of this study was to compare the cerebral protective effects of two known protective anesthetics, isoflurane and propofol, when these were used in combination with moderate hypothermia (33-34 degreesC) after diffuse traumatic brain injury (TBI) in the rat. We assessed cerebral protection by measuring local cerebral blood flow (LCBF), mean arterial blood pressure (MABP), cerebral perfusion pressure (CPP) and intracranial pressure (ICP).