Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.

Kahveci F., Kahveci N., Alkan T., Goren B., Korfali E., Ozluk K.

Surgical neurology, vol.56, no.3, pp.206-14, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 3
  • Publication Date: 2001
  • Doi Number: 10.1016/s0090-3019(01)00555-9
  • Journal Name: Surgical neurology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.206-14
  • Keywords: propofol, isoflurane, hypothermia, head injury, rat, LCBF, GLUCOSE-UTILIZATION, MILD HYPOTHERMIA, HEAD-INJURY, HIPPOCAMPAL GLUTAMATE, MODERATE HYPOTHERMIA, ELECTRICAL-ACTIVITY, ISCHEMIA, METABOLISM, HALOTHANE, ANTIOXIDANT
  • Bursa Uludag University Affiliated: Yes

Abstract

BACKGROUND The aim of this study was to compare the cerebral protective effects of two known protective anesthetics, isoflurane and propofol, when these were used in combination with moderate hypothermia (33-34 degreesC) after diffuse traumatic brain injury (TBI) in the rat. We assessed cerebral protection by measuring local cerebral blood flow (LCBF), mean arterial blood pressure (MABP), cerebral perfusion pressure (CPP) and intracranial pressure (ICP).