Expression of sex hormone-binding globulin, oxytocin receptor, caveolin-1 and p21 in leiomyoma


ŞENDEMİR E. , ŞENDEMİR E. , Kosmehl H., Jirikowsiu G. F.

GYNECOLOGICAL ENDOCRINOLOGY, vol.24, no.2, pp.105-112, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1080/09513590701690274
  • Title of Journal : GYNECOLOGICAL ENDOCRINOLOGY
  • Page Numbers: pp.105-112
  • Keywords: co-localization, fibroma, oxytocin, oxytocin receptor, p21, sex hormone-binding globulin, MESSENGER-RIBONUCLEIC-ACID, UTERINE LEIOMYOMAS, CANCER-CELLS, PROLIFERATION, PATHOGENESIS, ENDOMETRIUM, MYOMETRIUM, PROTEIN, GROWTH, LOCALIZATION

Abstract

Background. Interaction of sex hormone-binding globulin (SHBG) and oxytocin (OT) is among the factors that control smooth muscle proliferation and tumor growth through the oxytocin receptor (OTR). Also, a close functional interaction of OTR and caveolin-1 has been shown to modulate cell growth and proliferation.