Comparison of galactomannan, beta-D-glucan, and Aspergillus DNA in sera of high-risk adult patients with hematological malignancies for the diagnosis of invasive aspergillosis

Boluk G., Kazak E., Özkalemkaş F., Ener B., Akalin H., Ağca H., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.46, no.2, pp.335-342, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3906/sag-1408-100
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.335-342
  • Keywords: Invasive aspergillosis, galactomannan test, beta-D-glucan test, specific DNA, LINKED-IMMUNOSORBENT-ASSAY, REAL-TIME PCR, POLYMERASE-CHAIN-REACTION, CELL TRANSPLANT RECIPIENTS, FUNGAL-INFECTIONS, CIRCULATING GALACTOMANNAN, PULMONARY ASPERGILLOSIS, BRONCHOALVEOLAR LAVAGE, CLINICAL-EVALUATION, ANTIGEN-DETECTION
  • Bursa Uludag University Affiliated: Yes

Abstract

Bckground/aim: Invasive aspergillosis (IA) is a fatal infection that is difficult to diagnose in immunocompromised patients. In this study, Aspergillus-specific DNA was searched using real-time PCR (RT-PCR) in serum samples. Galactomannan (GM) and/or beta-D-glucan (BDG) tests were previously performed on these samples for 70 neutropenic patients with hematological malignancy.