Comparison of galactomannan, beta-D-glucan, and Aspergillus DNA in sera of high-risk adult patients with hematological malignancies for the diagnosis of invasive aspergillosis

Boluk, Gulcin; Kazak, ESRA; Özkalemkaş, FAHİR; Ener, BEYZA; Akalin, EMİN; Ağca, HARUN; Okuturlar, Yıldız; Keskin, Kursad; Burgazlioglu, Basak; Ali, RIDVAN

doi:10.3906/sag-1408-100

Comparison of galactomannan, beta-D-glucan, and Aspergillus DNA in sera of high-risk adult patients with hematological malignancies for the diagnosis of invasive aspergillosis

Boluk G., Kazak E., Özkalemkaş F., Ener B., Akalin H., Ağca H., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, sa.2, ss.335-342, 2016 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46 Sayı: 2
Basım Tarihi: 2016
Doi Numarası: 10.3906/sag-1408-100
Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.335-342
Anahtar Kelimeler: Invasive aspergillosis, galactomannan test, beta-D-glucan test, specific DNA, LINKED-IMMUNOSORBENT-ASSAY, REAL-TIME PCR, POLYMERASE-CHAIN-REACTION, CELL TRANSPLANT RECIPIENTS, FUNGAL-INFECTIONS, CIRCULATING GALACTOMANNAN, PULMONARY ASPERGILLOSIS, BRONCHOALVEOLAR LAVAGE, CLINICAL-EVALUATION, ANTIGEN-DETECTION
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Bckground/aim: Invasive aspergillosis (IA) is a fatal infection that is difficult to diagnose in immunocompromised patients. In this study, Aspergillus-specific DNA was searched using real-time PCR (RT-PCR) in serum samples. Galactomannan (GM) and/or beta-D-glucan (BDG) tests were previously performed on these samples for 70 neutropenic patients with hematological malignancy.