DNA damage in children treated with imipramine for primary nocturnal enuresis

Dundaroz R., Turkbay T., Surer I., Gok F., Denli M., Baltaci V.

PEDIATRICS INTERNATIONAL, vol.44, no.6, pp.617-621, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1442-200x.2002.01647.x
  • Page Numbers: pp.617-621


Background : Despite the fact that primary nocturnal enuresis (PNE) is self-limited and pathologically benign, the emotional stress and inconvenience that it produces, warrants treatment. Imipramine is one of the widely used drugs in PNE treatment. Although some mutagenic effects were suggested in imipramine administration, this toxicity has never been investigated in enuretic patients. The aim of this study was to evaluate the association of exposure to imipramine with DNA damage.