Akademik Veri Yönetim Sistemi
Arquivo Brasileiro De Medicina Veterinaria E Zootecnia, cilt.74, sa.1, ss.56-64, 2022 (SCI-Expanded)
The aim of this study was to investigate the anti-inflammatory effect of alcoholic extract of Tarantula cubensis
alcoholic extract (TCAE) in experimentally induced inflammation in rats. Fifty-four adult Sprague-Dawley
male rats were randomly divided into nine groups. Paw edema was induced by 0.2mL subplantar (s.p.)
injection of 1% carrageenan (CAR) into the right hind paw. Rats were treated with the nonsteroidal anti-
inflammatory drug (NSAID) indomethacin (INDO) (10mg/kg, p.o.) or TCAE at different doses (1, 10 or
100μg/kg) injected s.c. for systemic or s.p. for local anti-inflammatory effect. Saline was used as control.
Changes in paw thickness, volume, and weight were calculated as percentages. Formalin-fixed paws were used
for histopathological examination. We detected that TCAE applied s.c. at 10μg/kg and 100μg/kg doses resulted
in thinner paw thickness, lower paw volume, and lower paw weights four hours after the induction of
inflammation when compared with the INDO group (p<0.05). The paw edema inhibitory effect of TCAE
applied at a dose of 10μg/kg, s.c. was 68% when compared with the INDO which had an inhibitory effect of
56%. These results were verified with similar histopathological findings. The anti-inflammatory feature of
10μg/kg of TCAE given systematically was similar to the effects of INDO. Our results suggest that TCAE has
anti-inflammatory effects by reducing edema and decreasing inflammatory reaction. These results may be
attributed to the inhibition of the production of proinflammatory mediators. Thus, TCAE may be considered as
a potential anti-inflammatory agent for treating acute inflammatory conditions.