Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers

ERTÜRK BAKIR E., Enes Onur O., Akgun O., Tuna G., Yildiz Y., ARI F.

Mitochondrion, cilt.66, ss.74-81, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 66
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.mito.2022.08.002
  • Dergi Adı: Mitochondrion
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.74-81
  • Anahtar Kelimeler: Breast Cancer, miRNAs, Mitochondria, MitomiRs, TRANSCRIPTION FACTOR, MESSENGER-RNAS, MICRORNA, CELL, EXPRESSION, IMPORT, GENE, BIOGENESIS, APOPTOSIS, PROTEINS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. Although miRNAs mainly act in the cytoplasm, they can be found in the mitochondrial compartment of the cell. These miRNAs called “MitomiR”, they can change mitochondrial functions by regulating proteins at the mitochondrial level and cause cancer. In this review, we have aimed to explain miRNA biogenesis, transport pathways to mitochondria, and summarize mitomiRs that have been shown to play an important role in mitochondrial function, especially in the initiation and progression of breast cancer.