Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers

ERTÜRK BAKIR E., Enes Onur O., Akgun O., Tuna G., Yildiz Y., ARI F.

Mitochondrion, vol.66, pp.74-81, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 66
  • Publication Date: 2022
  • Doi Number: 10.1016/j.mito.2022.08.002
  • Journal Name: Mitochondrion
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.74-81
  • Keywords: Breast Cancer, miRNAs, Mitochondria, MitomiRs, TRANSCRIPTION FACTOR, MESSENGER-RNAS, MICRORNA, CELL, EXPRESSION, IMPORT, GENE, BIOGENESIS, APOPTOSIS, PROTEINS
  • Bursa Uludag University Affiliated: Yes

Abstract

Breast cancer is the most common cancer in women worldwide. MicroRNAs (miRNAs) are non-coding RNAs that are involved in the post-transcriptional regulation of gene expression. Although miRNAs mainly act in the cytoplasm, they can be found in the mitochondrial compartment of the cell. These miRNAs called “MitomiR”, they can change mitochondrial functions by regulating proteins at the mitochondrial level and cause cancer. In this review, we have aimed to explain miRNA biogenesis, transport pathways to mitochondria, and summarize mitomiRs that have been shown to play an important role in mitochondrial function, especially in the initiation and progression of breast cancer.