Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators


Bridoux A., Cui H., Dyskin E., Yalcin M. , Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.19, no.12, pp.3259-3263, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 12
  • Publication Date: 2009
  • Doi Number: 10.1016/j.bmcl.2009.04.094
  • Title of Journal : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Page Numbers: pp.3259-3263

Abstract

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity. (C) 2009 Published by Elsevier Ltd.