Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators

Bridoux A., Cui H., Dyskin E., Yalcin M., Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.19, sa.12, ss.3259-3263, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 12
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.bmcl.2009.04.094
  • Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3259-3263
  • Anahtar Kelimeler: Tetrac, Esterification, Silylation, HPLC, Angiogenesis, Nanopharmaceutical technology, INTEGRIN ALPHA-V-BETA-3, EXTRACELLULAR SEGMENT, CRYSTAL-STRUCTURE, TRIIODOTHYRONINE, THYROXINE, LIGAND, ACID
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity. (C) 2009 Published by Elsevier Ltd.