Semisynthesis and pharmacological activities of Tetrac analogs: Angiogenesis modulators

Bridoux A., Cui H., Dyskin E., Yalcin M., Mousa S. A.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.19, no.12, pp.3259-3263, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 12
  • Publication Date: 2009
  • Doi Number: 10.1016/j.bmcl.2009.04.094
  • Journal Name: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3259-3263
  • Keywords: Tetrac, Esterification, Silylation, HPLC, Angiogenesis, Nanopharmaceutical technology, INTEGRIN ALPHA-V-BETA-3, EXTRACELLULAR SEGMENT, CRYSTAL-STRUCTURE, TRIIODOTHYRONINE, THYROXINE, LIGAND, ACID
  • Bursa Uludag University Affiliated: Yes

Abstract

Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity. (C) 2009 Published by Elsevier Ltd.