Matrix metalloproteinase-9 (MMP-9) elevated in serum but not in bronchial lavage fluid in patients with lung cancer


Koc M., Ediger D., Budak F. , Karadag M., Oral H. B. , Uzaslan E., ...More

TUMORI J, vol.92, no.2, pp.149-154, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1177/030089160609200211
  • Title of Journal : TUMORI J
  • Page Numbers: pp.149-154
  • Keywords: bronchial lavage fluid, lung cancer, matrix metalloproteinase-9 (MMP-9), serum, ENDOTHELIAL GROWTH-FACTOR, MATRIX METALLOPROTEINASES, TISSUE INHIBITOR, IV COLLAGENASE, PLASMA, TIMP-1, BREAST

Abstract

Aims and background: Matrix metalloproteinase (MMP) family member MMP-9 degrades type IV collagen, which is one of the main constituents of the basement membrane. MMP-9 is closely associated with the invasive and metastatic potential of most types of lung cancer. In this study we investigated the levels of MMP-9 in serum and bronchial lavage fluid from lung cancer patients and compared them with the levels in patients with nonmalignant lung disease. We also attempted to clarify the possible relationship between serum and bronchial lavage fluid MMP-9 levels and histopathology, staging and metastasis of lung cancer.