The chondroprotective effects of intraarticular application of statin in osteoarthritis An experimental study

Bayyurt S., Kucukalp A., BİLGEN M. S., Bilgen O. F., Cavusoglu I., YALÇINKAYA Ü.

INDIAN JOURNAL OF ORTHOPAEDICS, cilt.49, sa.6, ss.665-671, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4103/0019-5413.168751
  • Dergi Adı: INDIAN JOURNAL OF ORTHOPAEDICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.665-671
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: Osteoarthritis (OA) is the most frequent chronic joint disease causing pain and disability. Recent reports have shown that statin may have the potential to inhibit osteoarthritis. This study of early stage OA developed in an experimental rabbit model, aimed to evaluate the chondroprotective effects of intraarticularly applied atorvastatin on cartilage tissue macroscopically and histopathologically by examining intracellular and extracellular changes by light and electron microscope.