The chondroprotective effects of intraarticular application of statin in osteoarthritis An experimental study

Bayyurt S., Kucukalp A., BİLGEN M. S., Bilgen O. F., Cavusoglu I., YALÇINKAYA Ü.

INDIAN JOURNAL OF ORTHOPAEDICS, vol.49, no.6, pp.665-671, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2015
  • Doi Number: 10.4103/0019-5413.168751
  • Journal Name: INDIAN JOURNAL OF ORTHOPAEDICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.665-671
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Osteoarthritis (OA) is the most frequent chronic joint disease causing pain and disability. Recent reports have shown that statin may have the potential to inhibit osteoarthritis. This study of early stage OA developed in an experimental rabbit model, aimed to evaluate the chondroprotective effects of intraarticularly applied atorvastatin on cartilage tissue macroscopically and histopathologically by examining intracellular and extracellular changes by light and electron microscope.