Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin


Sudha T., Yalcin M. , Lin H., Elmetwally A. M. , Nazeer T., Arumugam T., ...More

CANCER LETTERS, vol.350, pp.25-33, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 350
  • Publication Date: 2014
  • Doi Number: 10.1016/j.canlet.2014.04.016
  • Title of Journal : CANCER LETTERS
  • Page Numbers: pp.25-33

Abstract

Sulfated non-anticoagulant heparins (S-NACHs) might be preferred for potential clinical use in cancer patients without affecting hemostasis as compared to low molecular weight heparins (LMWHs). We investigated anti-tumor effects, anti-angiogenesis effects, and mechanisms of S-NACH in a mouse model of pancreatic cancer as compared to the LMWH tinzaparin. S-NACH or tinzaparin with or without gemcitabine were administered, and tumor luminescent signal intensity, tumor weight, and histopathology were assessed at the termination of the study. S-NACH and LMWH efficiently inhibited tumor growth and metastasis, without any observed bleeding events with S-NACH as compared to tinzaparin. S-NACH distinctly increased tumor necrosis and enhanced gemcitabine response in the mouse pancreatic cancer models. These data suggest the potential implication of S-NACH as a neoadjuvant in pancreatic cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.