THE EFFECT OF DICHLORVOS ON ACETYLCHOLINESTERASE ACTIVITY IN SOME TISSUES IN RATS

Dere E., ARI F., Ugur S.

ACTA VETERINARIA-BEOGRAD, cilt.60, ss.123-131, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2298/avb1003123d
  • Dergi Adı: ACTA VETERINARIA-BEOGRAD
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.123-131
  • Anahtar Kelimeler: acetylcholinesterase, DDVP (dichlorvos), PROTECTIVE ROLE, VITAMIN-E, METRIFONATE, DIAZINON, PESTICIDES, INDEXES
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

In this study, the changes with respect to time in the serum, brain, liver, kidney and small intestine acetylcholinesterase activities were investigated in both male and female rats administered dichlorvos intraperitoneally (i.p.). For this purpose, 4 mg kg(-1) doses of dichlorvos were injected i.p. in the rats. The control groups, on the other hand, were administered physiological saline via the same route. Rats were killed by decapitation at 0, 2, 4, 8, 16, 32, 64 and 72 hours after administration of dichlorvos and tissues were harvested. Enzyme activities were determined following the necessary treatments.