THE EFFECT OF DICHLORVOS ON ACETYLCHOLINESTERASE ACTIVITY IN SOME TISSUES IN RATS


Dere E., ARI F., Ugur S.

ACTA VETERINARIA-BEOGRAD, vol.60, pp.123-131, 2010 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2010
  • Doi Number: 10.2298/avb1003123d
  • Journal Name: ACTA VETERINARIA-BEOGRAD
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.123-131

Abstract

In this study, the changes with respect to time in the serum, brain, liver, kidney and small intestine acetylcholinesterase activities were investigated in both male and female rats administered dichlorvos intraperitoneally (i.p.). For this purpose, 4 mg kg(-1) doses of dichlorvos were injected i.p. in the rats. The control groups, on the other hand, were administered physiological saline via the same route. Rats were killed by decapitation at 0, 2, 4, 8, 16, 32, 64 and 72 hours after administration of dichlorvos and tissues were harvested. Enzyme activities were determined following the necessary treatments.