Assessment of the Efficacy of Bio-absorbable Oxidized Regenerated Cellulose for Prevention of Post-operative Pericardial Adhesion in the Rabbit Model

Bicer M. , Bayram A. S. , Gurbuz O., Senkaya I., Yerci O., Tok M., ...More

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.36, no.6, pp.1311-1318, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1177/147323000803600619
  • Page Numbers: pp.1311-1318


Pericardial adhesions complicate re-operative cardiac surgery and several attempts have been made to reduce adhesion formation. The efficacy of bio-absorbable oxidized regenerated cellulose in preventing post-operative pericardial adhesions was evaluated in the present study. Forty New Zealand white rabbits were divided into four groups of 10. In all rabbits an area of pericardium (2 x 2 cm) was excised. The wound was left open in groups I and 2 but replaced with bio-absorbable oxidized regenerated cellulose in groups 3 and 4. Rabbits in groups 1 and 3 were killed 3 weeks after surgery and those in groups 2 and 4 were killed at 6 weeks. Groups 1 and 2 showed more severe pericardial adhesions, more fibrous reaction and increased visibility of coronary vessels than groups 3 and 4, although there was no difference in inflammation. Light microscopy showed a mesothelium-like cell layer in groups 3 and 4. It is concluded that bio-absorbable oxidized regenerated cellulose may be suitable in patients receiving staged cardiac surgery and in those with a high probability of re-operation.