Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

Zhang, Tongyu; Xu, Shancai; Wu, Pei; Zhou, Keren; Wu, Lingyun; Xie, Zhiyi; Xu, Weilin; Luo, Xu; Li, Peng; Ocak, Umut; Ocak, PINAR; Travis, Zachary; Tang, Jiping; Shi, Huaizhang; Zhang, John

doi:10.1016/j.expneurol.2019.02.009

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

Zhang T., Xu S., Wu P., Zhou K., Wu L., Xie Z., ...Daha Fazla

EXPERIMENTAL NEUROLOGY, cilt.317, ss.1-9, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 317
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.expneurol.2019.02.009
Dergi Adı: EXPERIMENTAL NEUROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1-9
Anahtar Kelimeler: Mitoquinone, NF-E2-related factor 2, Prohibitin 2, Optic atrophy 1, Blood-brain barrier disruption, Subarachnoid hemorrhage, POSSIBLE INVOLVEMENT, INJURY, PROHIBITINS, INHIBITION, APOPTOSIS, NUCLEAR, DISEASE, EDEMA
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background and purpose: Mitochondrial dysfunction is involved in the mechanism of early brain injury (EBI) following subarachnoid hemorrhage (SAH). Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone (MitoQ) in blood-brain barrier disruption after SAH in rats.