An Unexpected Malignancy Behind Pediatric Microangiopathic Hemolytic Anemia: Gastric Signet Ring Cell Carcinoma
Journal of Pediatric Hematology/Oncology, cilt.48, sa.6, ss.1-5, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Vaka Takdimi
- Cilt numarası: 48 Sayı: 6
- Basım Tarihi: 2026
- Doi Numarası: 10.1097/mph.0000000000003240
- Dergi Adı: Journal of Pediatric Hematology/Oncology
- Derginin Tarandığı İndeksler: Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, CINAHL, EMBASE, PubMed
- Sayfa Sayıları: ss.1-5
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Background: In the pediatric population, gastrointestinal (GIS) cancers are rare, and paraneoplastic syndromes associated with these malignancies are even more uncommon.
Observations: A 15-year-old patient with a clinical presentation of microangiopathic hemolytic anemia (MAHA) resistant to plasma exchange was found to have metastatic adenocarcinoma in a biopsy of a supraclavicular lymphadenopathy. Subsequent endoscopy revealed gastric signet ring cell carcinoma.
Conclusions: This case highlights that malignancy should be suspected in pediatric patients with MAHA who are unresponsive to plasma exchange and have normal ADAMTS-13 activity. Key Words: microangiopathic hemolytic anemia, gastric signet ring cell carcinoma, pediatric