Induction of sister chromatid exchanges by pyrimethamine in human lymphocyte cultures
TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, cilt.18, sa.4, ss.163-169, 1998 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 4
- Basım Tarihi: 1998
- Dergi Adı: TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.163-169
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/ml. The results of the cytogenetic and statistical evaluations showed that the frequency of SCEs increased significantly in a dose-dependent manner. Thus, it is shown that PYR has a genotoxic effect on human chromosomes. Teratogenesis Carcinog. Mutagen. 18:163-169, 1998. (C) 1998 Wiley-Liss, Inc.