Synthesis, anticorrosion, antibacterial, and antifungal activity of new amphiphilic compounds possessing quinazolin-4(3H)-one scaffold


Ozturk S., Okay S., Yildirim A.

RUSSIAN CHEMICAL BULLETIN, vol.69, no.11, pp.2205-2214, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 11
  • Publication Date: 2020
  • Doi Number: 10.1007/s11172-020-3023-0
  • Journal Name: RUSSIAN CHEMICAL BULLETIN
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.2205-2214
  • Keywords: anticorrosion activity, antibacterial activity, antifungal activity, heterocyclic surfactants, quinazolin-4(3H)-one, Gibbs free energy of micellization
  • Bursa Uludag University Affiliated: Yes

Abstract

For the first time, quinazolin-4(3H)-one-based cationic surfactants were prepared and fully characterized by IR and NMR spectroscopic techniques and elemental analysis. Some of their physicochemical properties, such as density, critical micelle concentration, surface tension, effectiveness in surface tension reduction, Gibbs free energy of micellization, foam and emulsion stability, and anticorrosion activity were determined. Antibacterial and antifungal activities of the synthesized compounds were investigated. N,N-Dimethyl-N-{2-[(2-methyl-4-oxoquinazolin-3(4H)-yl)amino]-2-oxoethyl}tetradecan-1-aminium chloride (4a) showed the highest antibacterial activity against five human pathogens. Antifungal activity against Candida albicans was shown only by surfactant 4a.