Synthesis, anticorrosion, antibacterial, and antifungal activity of new amphiphilic compounds possessing quinazolin-4(3H)-one scaffold

Ozturk S., Okay S., Yildirim A.

RUSSIAN CHEMICAL BULLETIN, cilt.69, sa.11, ss.2205-2214, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s11172-020-3023-0
  • Dergi Adı: RUSSIAN CHEMICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.2205-2214
  • Anahtar Kelimeler: anticorrosion activity, antibacterial activity, antifungal activity, heterocyclic surfactants, quinazolin-4(3H)-one, Gibbs free energy of micellization
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

For the first time, quinazolin-4(3H)-one-based cationic surfactants were prepared and fully characterized by IR and NMR spectroscopic techniques and elemental analysis. Some of their physicochemical properties, such as density, critical micelle concentration, surface tension, effectiveness in surface tension reduction, Gibbs free energy of micellization, foam and emulsion stability, and anticorrosion activity were determined. Antibacterial and antifungal activities of the synthesized compounds were investigated. N,N-Dimethyl-N-{2-[(2-methyl-4-oxoquinazolin-3(4H)-yl)amino]-2-oxoethyl}tetradecan-1-aminium chloride (4a) showed the highest antibacterial activity against five human pathogens. Antifungal activity against Candida albicans was shown only by surfactant 4a.