THE CYTOTOXIC EFFECT OF USNIC ACID IN MALIGNANT MELANOMA CELLS WITH DIFFERENT GENOMIC PROFILES IN THE BRAF ASPECT


Colakoglu C., Haciefendi A., Eryilmaz I. E., Eskiler G. G., Egeli U., ÇEÇENER G.

WORLD CANCER RESEARCH JOURNAL, vol.9, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2022
  • Doi Number: 10.32113/wcrj_20223_2240
  • Journal Name: WORLD CANCER RESEARCH JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: Usnic acid, Malignant melanoma, Cytotoxic effect, BRAF mutation, CYCLE ARREST, AUTOPHAGY, APOPTOSIS
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: Malignant melanoma (MM) is the most aggressive skin cancer and treatment options are still limited in the late stages, generally accompanied by BRAF mutations. Usnic acid (UA), a well-known traditional lichen metabolite, has a promising and selective antitumoral activity. However, the effects of UA on MM cells with different genomic profiles in the BRAF aspect have not been investigated yet. In this study, we evaluated the effect of UA on BRAFV600E mutated-A2058 and wild-type MeWo cells.