IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B-12 CONCENTRATIONS
NOBEL MEDICUS, cilt.9, sa.2, ss.15-20, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 2
- Basım Tarihi: 2013
- Dergi Adı: NOBEL MEDICUS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.15-20
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Objective: Subclinical vitamin B-12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B-12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B-12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B-12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.