IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B-12 CONCENTRATIONS

Sonmezisik F., GÜR E., Asiltas B.

NOBEL MEDICUS, cilt.9, sa.2, ss.15-20, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: NOBEL MEDICUS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.15-20
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: Subclinical vitamin B-12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B-12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B-12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B-12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.