IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B-12 CONCENTRATIONS

Sonmezisik F., GÜR E., Asiltas B.

NOBEL MEDICUS, vol.9, no.2, pp.15-20, 2013 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2013
  • Journal Name: NOBEL MEDICUS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.15-20
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective: Subclinical vitamin B-12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B-12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B-12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B-12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.