IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B-12 CONCENTRATIONS


Sonmezisik F., GÜR E. , Asiltas B.

NOBEL MEDICUS, vol.9, no.2, pp.15-20, 2013 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 2
  • Publication Date: 2013
  • Title of Journal : NOBEL MEDICUS
  • Page Numbers: pp.15-20

Abstract

Objective: Subclinical vitamin B-12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B-12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B-12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B-12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.