Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders?


Baric I., ERDÖL Ş., SAĞLAM H., Lovric M., Beluzic R., Vugrek O., ...Daha Fazla

JIMD REPORTS, VOL 31, cilt.31, ss.101-106, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/8904_2016_543
  • Dergi Adı: JIMD REPORTS, VOL 31
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.101-106
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Glycine N-methyltransferase deficiency is an inherited disorder of methionine metabolism, reported so far in only four patients and characterised by permanent hypermethioninemia. This disorder has been considered as probably benign because moderate hepatomegaly in two patients was the only obvious symptom and mild to moderate elevation of aminotransferases the only laboratory abnormality. Our experience with the current novel patient points out that this disease, due to very high hypermethioninemia, is not harmless and that there may be diagnostic pitfalls in interpretation of biochemical hallmarks of the disease. Since the first description of glycine N-methyltransferase deficiency, other disorders of this metabolic pathway affecting the liver have been reported pointing to dysmethylation as the common pathogenetic mechanism. Therefore, we suggest the whole group to be named dysmethylating liver diseases.