Choline potentiates the pressor response evoked by glycyl-glutamine or naloxone in haemorrhaged rats

Gurun M. S., Millington W., Ulus I.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.30, sa.9, ss.640-642, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1046/j.1440-1681.2003.03886.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.640-642
  • Anahtar Kelimeler: choline, cholinergic system, glycyl-glutamine, Gly-Gln, haemorrhage, hypotension, opioid, ACETYLCHOLINE TURNOVER, MORPHINE, SHOCK, PHYSOSTIGMINE, REVERSAL, DEPRESSION, ANTAGONISM, ENDORPHIN, DECREASE, BRAIN
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

1. Severe blood loss initially lowers arterial pressure through a central mechanism that is thought to involve opioid and cholinergic neurons. The present study tested the hypothesis that simultaneous administration of a cholinergic agonist and an opioid receptor antagonist would produce a synergistic effect in the treatment of haemorrhage. Specifically, we tested whether choline, a precursor of acetylcholine, potentiates the pressor effect of the beta-endorphin derived peptide glycylglutamine (Gly-Gln) or the opioid receptor antagonist naloxone following acute haemorrhage.