Neuromedin U and BMI correlation in T1DM and T2DM vs healthy controls: A comparative study Neuromedina U y su correlación con el índice de masa corporal en pacientes diabéticos: un estudio comparativo de diabetes tipo 1, tipo 2 y controles sanos

Çalışkan Y., SARANDÖL E., Koca N.

Endocrinologia, Diabetes y Nutricion, cilt.72, sa.8, 2025 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 8
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.endinu.2025.501631
  • Dergi Adı: Endocrinologia, Diabetes y Nutricion
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, MEDLINE, DIALNET
  • Anahtar Kelimeler: Body mass index, Diabetes mellitus tipo 1, Diabetes mellitus tipo 2, Metabolic regulation, Neuromedin U, Neuromedina U, Regulación metabólica, Type 1 diabetes mellitus, Type 2 diabetes mellitus, Índice de masa corporal
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to assess serum Neuromedin U (NmU) levels in patients with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM) vs healthy controls and evaluate the correlation between NmU and body mass index (BMI). Research design and methods: We conducted a cross-sectional study with 134 participants: 45 with T1DM, 49 with T2DM, and 40 healthy controls. Serum NmU levels were measured using enzyme-linked immunosorbent assay (ELISA), and the correlation with BMI was assessed. Results: NmU levels were not significantly different between diabetic patients and healthy controls. No significant correlation was observed between NmU and BMI in T1DM or T2DM groups. However, the healthy control group found a significant inverse correlation between NmU and BMI (rho = −0.373, p < 0.05). Conclusions: NmU may not be a direct biomarker for diabetes, but its significant correlation with BMI in healthy individuals suggests a potential role in metabolic regulation. This is the first study ever conducted to compare NmU levels across diabetic subtypes, offering novel insights into the role of in metabolic homeostasis.