Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro

YILMAZ D., Teksoy O., Bilaloglu R., ÇİNKILIÇ N.

DRUG AND CHEMICAL TOXICOLOGY, vol.39, no.2, pp.119-123, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.3109/01480545.2015.1039647
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-123
  • Bursa Uludag University Affiliated: Yes


Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of naringin (1, 2, 3 mu g/mL) and a single dose of BLM (20 mu g/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 mu g/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 mu g/mL. Combined treatments of BLM and naringin (2 and 3 mu g/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that naringin could prevent BLM (20 mu g/mL)-induced genotoxicity.