Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats

KOYUNCUOĞLU T., Turkyilmaz M., GÖREN B., Cetinkaya M., CANSEV M., ALKAN T.

RESTORATIVE NEUROLOGY AND NEUROSCIENCE, cilt.33, sa.5, ss.777-784, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3233/rnn-150549
  • Dergi Adı: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.777-784
  • Anahtar Kelimeler: Hypoxic-ischemic encephalopathy, neonatal, rat, uridine, histone deacetylase, neuroprotection, DOCOSAHEXAENOIC ACID, CDP-CHOLINE, INHIBITION, MODEL, COMBINATION, DAMAGE, NEURODEGENERATION, NEUROPROTECTION, MECHANISMS, RECEPTORS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Purpose: A significant cause of neurological disability in newborns is hypoxic-ischemic encephalopathy (HIE), a disorder which involves an enhancement in histone deacetylase (HDAC) activity among underlying pathological mechanisms. We showed recently that exogenous administration of uridine to newborn rats with HIE reduced brain injury in a dose-dependent manner. The present study was performed to investigate whether uridine modulates histone acetylation/deacetylation balance in a neonatal rat model of HIE.