A NEW SYNTHESIS OF N-SUBSTITUTED-1,2,3,4-TETRAHYDRO-4-PHENYLISOQUINOLIN-3-ONES

COSKUN N., SUMENGEN D.

SYNTHETIC COMMUNICATIONS, cilt.23, sa.10, ss.1393-1402, 1993 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 10
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1080/00397919308011228
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1393-1402
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate ( LTA ) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage ( method B or C ), or two stages ( method A ). The latter method was particularly developed to explain the mechanism of the reaction.