A NEW SYNTHESIS OF N-SUBSTITUTED-1,2,3,4-TETRAHYDRO-4-PHENYLISOQUINOLIN-3-ONES


COSKUN N. , SUMENGEN D.

SYNTHETIC COMMUNICATIONS, vol.23, no.10, pp.1393-1402, 1993 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 10
  • Publication Date: 1993
  • Doi Number: 10.1080/00397919308011228
  • Title of Journal : SYNTHETIC COMMUNICATIONS
  • Page Numbers: pp.1393-1402

Abstract

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate ( LTA ) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage ( method B or C ), or two stages ( method A ). The latter method was particularly developed to explain the mechanism of the reaction.