Neoadjuvant chemotherapy-induced changes in immunohistochemical expression of estrogen receptor, progesterone receptor, HER2, and Ki-67 in patients with breast cancer

Avci N., DELİGÖNÜL A., TOLUNAY Ş., ÇUBUKÇU E., Olmez O. F., Ulas A., ...More

JOURNAL OF BUON, vol.20, no.1, pp.45-49, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2015
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-49
  • Keywords: breast cancer, estrogen/progesterone receptor, HER2, immunohistochemistry, Ki-67, neoadjuvant chemotherapy, KI67
  • Bursa Uludag University Affiliated: Yes


Purpose: The impact of neoadjuvant chemotherapy (NACT) on immunohistochemical markers in breast cancer specimens remains controversial. We designed the current study to investigate the potential changes in estrogen receptor (ER), progesterone receptor (PR), HER2, and Ki-67 expression before and after NACT in a cohort of Turkish patients with breast cancer.