Akademik Veri Yönetim Sistemi
4th. INTERNATIONAL ANTALYA SCIENTIFIC RESEARCH AND INNOVATIVE STUDIES, Antalya, Türkiye, 9 - 10 Mayıs 2023, ss.1-2
Pelvic organ
prolapse (POP) disorders negatively affect life of many women around world.
Depending on various factors such as age, obesity, menopause, smoking, number
and type of birth, prevalence of POP in society is rapidly increasing. Especially,
POP seriously affects life quality of the older women.
Surgical methods
commonly use to treatment of POP is the implantation of synthetic mesh or
biological grafts designed to restore anatomical function of the pelvic floor.
The mechanical
properties of biological grafts are insufficient and their use is limited due
to risks such as, finite donor tissue and wound infection. The synthetic
polypropylene (PP) knitted meshes have already widely used. However, their use
is questioned due to complications, erosion and chronic pain that occur after
POP repair surgery.
New approaches for
surgical mesh used in POP disorders are to improve mesh performance and safety
by using different fabrication methods. The importance of electrospun surfaces
which have nano-scale diameters of fibers are increasing day by day in the
fields of regenerative medicine and tissue engineering, thanks to their
superior properties and biocompatible structures. Due to their fibrillary
structure, scaffolds derived from electrospun surface could mimic the
extracellular matrix (ECM) of the connective tissue in the human body.
In this study; it
was aimed to produce and characterize nanofiber mesh by electrospinning method
for use in the treatment of POP. For this purpose, study was carried out to
produce polyurethane (PU) electrospun nanofiber mesh that is biocompatible and
has no cytotoxic activity. The produced nanofiber mesh was characterized in
terms of mechanical (burst strength), morphological (porosity), performance
(weight, thickness, air permeability) and biocompatibility (cytotoxicity, cell
adhesion potential). The obtained results were compared with properties of a
commercial PP mesh used in POP treatment.
Keywords: Biomaterial, polyurethane,
nanofiber, electrospinning, pelvic organ prolapse, in vitro