Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine.

Tunca B., Egeli Ü., Aydemir N., Cecener G., Bilaloglu R.

Teratogenesis, carcinogenesis, and mutagenesis, vol.22, no.6, pp.393-402, 2002 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1002/tcm.10036
  • Journal Name: Teratogenesis, carcinogenesis, and mutagenesis
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.393-402


In the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations. (C) 2002 Wiley-Liss, Inc.