Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine.

Tunca B., Egeli Ü., Aydemir N., Cecener G., Bilaloglu R.

Teratogenesis, carcinogenesis, and mutagenesis, cilt.22, sa.6, ss.393-402, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1002/tcm.10036
  • Dergi Adı: Teratogenesis, carcinogenesis, and mutagenesis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.393-402
  • Anahtar Kelimeler: pyrimethamine, chromosome aberrations, micronucleus, bone marrow, Swiss albino mice, COMMON FRAGILE SITES, IN-VIVO MOUSE, FHIT GENE, CHROMOSOME-ABERRATIONS, LYMPHOCYTE-CULTURES, SPINDLE POISONS, CHL CELLS, EXPRESSION, INDUCTION, CANCER
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

In the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations. (C) 2002 Wiley-Liss, Inc.