Teratogenesis, carcinogenesis, and mutagenesis, vol.22, no.6, pp.393-402, 2002 (SCI-Expanded)
Article / Article
Teratogenesis, carcinogenesis, and mutagenesis
Science Citation Index Expanded (SCI-EXPANDED), Scopus
pyrimethamine, chromosome aberrations, micronucleus, bone marrow, Swiss albino mice, COMMON FRAGILE SITES, IN-VIVO MOUSE, FHIT GENE, CHROMOSOME-ABERRATIONS, LYMPHOCYTE-CULTURES, SPINDLE POISONS, CHL CELLS, EXPRESSION, INDUCTION, CANCER
Bursa Uludag University Affiliated:
In the present study, we investigated the genotoxic effect of pyrimethamine, which is a drug used in the therapy of toxoplasmosis and malaria, in bone marrow cells of Swiss albino mice exposed to three doses (1, 4, 8 mg/kg) of this agent for eight months orally in vivo. We used a chromosome analysis and micronucleus test for evaluation of genotoxic effect. While a statistically significant change was not determined in numerical chromosome abnormalities, structural chromosome aberrations and micronuclei were increased in a dose-dependent manner by cytogenetic and statistical evaluations. (C) 2002 Wiley-Liss, Inc.