Effects of Different Onset Times of Early Caffeine Treatment on Mesenteric Tissue Oxygenation and Necrotizing Enterocolitis: A Prospective, Randomized Study

ÖZKAN H., Cetinkaya M., Cakir S. Ç., Saglam O., KÖKSAL F. N.

AMERICAN JOURNAL OF PERINATOLOGY, vol.40, no.1, pp.28-34, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1055/s-0041-1727157
  • Journal Name: AMERICAN JOURNAL OF PERINATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.28-34
  • Keywords: caffeine, mesenteric tissue oxygen saturation, necrotizing enterocolitis, newborn
  • Bursa Uludag University Affiliated: Yes

Abstract

Objective Caffeine treatment is routinely used in premature infants to prevent development of apnea and bronchopulmonary dysplasia. Although a limited number of studies have reported that early caffeine treatment may cause development of necrotizing enterocolitis (NEC) by reducing mesenteric blood flow, this issue is still under discussion. The aim of this study is to investigate the possible effect of different onset times of early caffeine treatment on mesenteric tissue oxygen saturation and NEC development in premature infants.